Etiology of Newborn Malformations

Etiology Incidence
Genetic 15-25%
Chromosomal 10-15%
Single Gene 2-10%
Multifactorial 20-25%
Environmental 8-12%
Maternal Disease 6-8%
Uterine/Placental 2-3%
Drugs/Chemical 0.5-1%
Twinning 0.5-1%
Unknown 40-60%

Stevenson, R.  1993.  Human Malformation
and Related Anomalies.

Genetics
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Last modification: February 21, 1998