Hodgkins Disease

Now that more of the biology of Hodgkins has been uncovered, it appears that it can be divided into lymphocyte predominant HD, and "classic" HD which would include the nodular sclerosing, mixed cellularity, and lymphocyte depleted variants. In the classic HD, the malignant cell is the Reed Sternberg cell which can have several different appearances. It is believed that all forms of HD are of B cell origin.

Hodgkins disease is characterized by contiguous spread; metastasis is a late event. The staging system reflects this:

I	Single node region (or extralymphatic site = I_E)
II	Two or more LN on same side of diaphragm (or sites, II_E)
III	LN (or sites) on both sides of the diaphragm (III_E, extranodal, III_S, spleen; III_ES, both)
IV	Mulitiple or disseminated spread

Lymphomas

Heme-Onc

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Last modification: April 30, 1999