| Description |
This variant has the worst prognosis of the Hodgkins lymphomas.
It presents with abdominal lymphadenopathy, and may involve the spleen,
liver and marrow. Peripheral lymphadenopathy is rare. Two subdivisions
are recognized: diffuse (fibrotic) with extensive connective tissue and
Reed Sternberg cells and a reticular type, which is also known as Hodgkins
lymphoma and is similar if not identical to anaplastic large cell lymphoma
(Ki-1 lymphoma). |
| Frequency |
This is the least common HD variant and is sometimes seen in older,
HIV+ patients. |
| Cytogenetics |
| Locus |
Product |
Description |
|
| Markers |
| Positive |
CD 30 |
| +/- |
CD 15 |
| Negative |
CD 45; No B or T specific antigens |
|
