| Description |
The lymphocyte predominant form of HD is biologically distinct from
the "classic" forms of Hodgkins Disease. Cervical and axillary lymph
nodes are common, but mediastinal invovlement and extranodal disease are
rare. LP may transform to diffuse large B-cell lymphoma. Morphologically,
the node may be follicular or diffuse. LH (Langerhans histiocyte-variant
Reed Sternberg) cells are the large "popcorn" cells with vaculoated nuclei,
small nucleoli and scant cytoplasm. Centrocytes are not seen.
Necrosis is rare and fibrosis is absent. |
| Frequency |
More common in males than females; usually presents in the fourth decade
of life. |
| Cytogenetics |
| Locus |
Product |
Description |
|
|
|
|
| Markers |
| Positive |
J-chains, CD 20, 30, 45, w75 |
| +/- |
CD 30, EMA |
| Negative |
CD 15 |
|
