| Description |
In an unstimulated lymph node, the primary
follicle is composed of unactivated B cells and some dendritic cells..
When a secondary follicle forms, the follicular B cells are pushed outwards,
forming a shell which is more pronouced an the side of the follicle away
from the hilum. Mantle cell lymphomas are derived from such cells.
MCL is often advanced at the time of diagnosis and may affect lymph nodes
including Waldeyer's Ring, bone marrow, blood, the liver, spleen, or may
become multifocal in the bowel, a condition known as lymphoid polyposis.
In this condition, nodules are seen in the lamina propria, particularly
of the colon. Microscopically, the cells are small to medium lymphoid
cells, monotonous in appearance or in a starry sky pattern secondary to
occassional pale-staining lymphocytes. |
| Frequency |
Mantle cell lymphomas are about 5% of NHL
in the U.S., and occur in males more than females, usually in the fifth or
sixth decade. |
| Cytogenetics |
| Locus |
Product |
Description |
| t(11;14) |
bcl-1 rearrangement |
bcl-1 codes for Cyclin D1, a cell cycle regulatory protein |
|
| Markers |
| Positive |
sIgM, sIgD, lambda or kappa chains, CD 19, 20, 22, 43, Cyclin D1 |
| +/- |
CD5 |
| Negative |
CD10, usually CD23 negative |
|
