| Description |
These lymphomas arise in middle age adults at sites of autoimmune or
infectious stimulation (the three common examples are in the thyroid with
Hashimoto thyroiditis, in the salivary glands with Sjorgren's syndrome
or in the stomach with H. pylori infection). This lymphoma
may under transformation to diffuse large B-cell lymphoma. If the
lesion is associated with lymphoid tissue, it may be referred to as a MALToma
(mucous-associated lymphoid tissue tumor). The cells correspond to
the marginal B-cells found at the periphery of stimulated lymphoid follicles,
centrocytes and monocytoid B cells. |
| Frequency |
|
| Cytogenetics |
| Locus |
Product |
Description |
| No known gene rearrangements have
been identified. |
|
| Markers |
| Positive |
sIg, B cell antigens (CD 19, 20, 22, 79a) |
| +/- |
CD 11c, 43 |
| Negative |
CD5, 10, 23 |
|
