| Description |
In this disorder, the transformed cells are B lymphocytes, but they
are surrounded reactive T lymphocytes (distinguished by positive CD 3,
45RO, and 43). Constitutional symptoms are common, and the disease
often presents in an advanced state. |
| Frequency |
This category accounts for only 1% of NHL. It is primarily a
disease of older males. |
| Cytogenetics |
| Locus |
Product |
Description |
t(2;8)
t(8;14)
t(8;22) |
|
myc rearrangements (chromosome 8) |
|
| Markers |
| Positive |
CD 10, 19, 20, 22, 79a, sIgM, lambda or kappa chains. |
| +/- |
|
| Negative |
CD 3, 23 |
|
