Interpretation of Hemoglobin Electrophoresis

Syndrome	Hgb	MCV	% A	%A2	%F	% other	comment
normal	13	85	95	< 3.5	< 2
thal trait	12.5	70	90	> 3.5	< 8		some targets
thal major	6	65	< 30	> 5	> 60		nRBCs, spleen
S trait (AS)	13	85	60	< 3.5	< 2	S 40	nl smear + S prep
S trait/alpha thal trait	13	80	70	< 3.5	< 2	S 30	S prep
S/+ thal	10	65	25	> 3.5	< 20	S 70	S prep; S > A
S/0 thal	8	65	0	> 3.5	< 30	S 90	S prep
SS disease	7	85	0	< 3.5	< 30	S 90	S prep
SS/alpha thal	8	75	0	< 3.5	< 35	S 90	S prep
SC disease	10	80	0	< 3.5	< 2	S 50, C 50	S prep, many targets
C trait (AC)	13	85	50	< 3.5	< 2	C 50	targets, sphero
CC disease	12	80	0	< 3.5	< 2	C 95	targets, sphero
alpha silent carrier	13	85	95	< 3.5	< 2		nl smear
alpha thal trait	10	80	95	rarely > 3.5	< 2		some targets
Hgb H disease	10	70	90	< 3.5	< 5	H 2.5	+/- inclusions
E trait	13	70	70	< 3.5	< 2	E 30	targets
AE/alpha thal	13	65	80	< 3.5	< 2	E 20	targets
Hgb EE	11	60	0	< 3.5	< 8	E 90	targets
E/0 thal	8	60	0	> 3.5	< 10	E 80	targets, nRBC, spleen