| Name | Etoposide
vp-16 |
| MW | 588 |
| Category | Epipodophyllotoxin |
| Binding Mode | Topoisomerase II inhibitor, generally believed not to interact directly with DNA. However, one report [Chow, 1988] states that it binds infrequent sites, binds supercoiled and linear DNA equally, and binds ssDNA more than dsDNA. |
| Site Specificity | Unknown. |
| Effect on DNA | Unwinding angle of 17o [Waring, 1981]. |
| Preparation and Use | Limited solubility in water. |
| DNA drugs |
| Heme-Onc |
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