| Name |
Hoescht 33258[2(4-hydroxyphenyl)-5[5-(4-methylpiperazine-1-yl)-
benzimidazol-2-yl]benzimidazole] (bisbenzimide) |
| MW |
623.97 (Aldrich) |
| CAS# |
23491-45-4 |
| Category |
Benzimide |
| Binding Mode |
Binding Mode: Minor groove, covers 4-5 base pairs in xray crystal
[Goodsell, 1986; Pjura, 1987] and 4 base pairs in NMR solution structure
[Searle, 1990]. |
| Site Specificity |
5'-WWWW-3' [Goodsell, 1986; Searle, 1990] |
| Effect on DNA |
Minimal distortion of helix, bends helix 6-8o [Pjura, 1987]. |
| Source |
Obtained from Aldrich Chemical Co (Milwaukee, WI). Originally
synthesized by Hoescht, not a natural product. |
| Preparation and Use |
Prepared in ddH2O |
