DNA-Interactive Drugs: Menogaril


 
Name Menogaril 
7-OMEN 
7(R)-O-methylnogarol 
U-52047 
TUT-7
CAS#  71628-96-1
NCS#  269148
MW 541.54 (MSDS from Upjohn)
Category Anthracycline
Binding Mode Presumed to be intercalation, although interaction with DNA is much weaker than with parent nogalamycin [Li, 1979]
Site Specificity Unknown
Effect on DNA Increases duplex Tm slightly, weak DNA interaction by CD analysis [Li, 1979].
Preparation and Use Dissolve in DMSO, heat to 37oC in water bath, vortex into solution.
 
DNA drugs
Heme-Onc
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Please direct all comments to: Jack Welch, M.D., Ph.D.
Last Modified August 1, 1998Last modification: August 10, 1998