| Name | Mitoxantrone
DHAQ 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]- 9,10-anthracenedione Novatrone |
| CAS# | 70476-82-3 |
| NCS# | 279836, 301739 (as salt) |
| MW | 444.09 |
| Category | Anthracenedione (aminoalkylanthracene) |
| Binding Mode | Intercalation [Kapuscinski, 1981] |
| Site Specificity | None, by spectrophotometric titration with various DNAs [Kapuscinski, 1985], G/C by spectrophotometric titration with various DNAs (under slightly different conditions) [Lown, 1985] |
| Effect on DNA | At relatively low concentrations, condenses DNA [Kapuscinski, 1985]. DNA unwinding angle reported as 17.5o by Lown [Lown, 1985], and 26.5o by Kapuscinski [Kapuscinski, 1981] |
| Preparation and Use | Isobestic point 682 nm with extinction coefficient of 8.36 x 103 cm-1M-1 [Kapuscinski, 1985]. 5 mM stock prepared in DMSO. Dry powder should be stored at room temperature and not frozen. Navy blue crystals and solution. |
| DNA drugs |
| Heme-Onc |
| Netscut Home |