| Name | Netropsin
Congocidin Antibiotic T-1384 |
| CAS# | 554-32-5 |
| MW | 539.3 (Boehringer Mannheim) |
| Category | Pyrrolocarboximide |
| Binding Mode | Minor groove binding, as demonstrated by x-ray crystal structure [Kopka, 1985] |
| Site Specificity | A/T preference based on MPE-Fe(II) footprinting [van Dyke, 1982]. |
| Effect on DNA | Monomer binding has almost no effect on DNA conformation [Patel, 1985]. Minimal overall helical distortion, slight minor groove widening at drug site and compensatory shift in sugar-backbone, helix bent 8o toward major groove [Kopka, 1985]. |
| Source | Initially isolated from Streptomyces netropsis [Finlay, 1951]. |
| Preparation and Use | Dissolve in ddH2O. Extinction coefficient 2.02x104 M-1 cm-1 at 296 nm. Store powder at 4oC, solution stored at -20oC. |
| DNA drugs |
| Heme-Onc |
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