| Name | Tilorone
2,7-bis[2-(diethylamino)ethoxyl]-fluoren-9-one |
| Binding Mode | Intercalation |
| Site Specificity | Initially believed to have A/T preference based on spectrophotometry with synthetic DNA fragments demonstrated A/T preference [Chandra, 1974], and theoretical modelling [Chen, 1988]. Mixed, alternating purine-pyrimidine sequences based on footprinting [Sturm, 1982; Bailly, 1993] |
| Effect on DNA | Unwinding angle of approximately 13o [Waring, 1981]. |
| Preparation and Use | 5 mM stock in DMSO |
| DNA drugs |
| Heme-Onc |
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