| Name |
U-73,975 |
| CAS# |
123219-86-3 |
| MW |
502.5 (Upjohn) |
| Category |
Cyclopropylpyrroloindole |
| Binding Mode |
Minor groove binding drug, forms covalent adduct to N3-A |
| Site Specificity |
Consensus sequence determined to be (W)WA*(C/G)(G) where A* is the
adducted adenine, and bases in parenthesis are a preference, but not an
absolute requirement [Weiland, 1991] |
| Source |
Synthetic analog of CC-1065 |
| Preparation and Use |
Initial stock are prepared from powder, 2mg/mL in N,N dimethylacetamide.
Substock diluted to 2.5mM with DMSO. Further dilutions are prepared
with water. Extinction coefficient 40282 M-1 cm-1
at 310 nm. |
