DNA-Interactive Drugs: Ametantrone


 
Name Ametantrone 
1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione)
NCS 287513
Category Anthracenedione (aminoalkylanthracene)
Binding Mode Intercalation
Site Specificity Alternating A/T, by spectrophotometric titration [Kapuscinski, 1985]
Effect on DNA At high concentrations, condenses DNA
Preparation and Use Hygroscopic.  Isobestic point 645 nm with extinction coefficient of 7.05 x 103 cm-1M-1 [Kapuscinski, 1985].  5 mM stock prepared in DMSO. 
 
DNA drugs
Heme-Onc
Netscut Home

Please direct all comments to: Jack Welch, M.D., Ph.D.
Last Modified August 1, 1998