| Name | Amiloride HCl
Midamor 3,5-diamino-6-chloro-N-(diaminomethylene) pyrazinecarboxamide |
| MW | 229.65 |
| Category | Pyrazine derivative |
| Binding Mode | Intercalation. |
| Site Specificity | A/T preference, by DNA cleavage inhibition [Bailly, 1993]. |
| Preparation and Use | E1%1cm at 285 nm is 555 OD, and E1%1cm at 362 nm is 617 OD (ie, 1g of this compound in 100 ml total volume would have an absorbance of 555 O.D. units at a wavelength of 285 nm, measured with a 1 cm light path). Tablets have been found not to dissolve directly in DMSO. Drug should be dissolved in the minimal amount of ddH2O necessary, and then brought to a final volume in DMSO. The solution can then be filtered, first through Whatman paper, then through a nitrocellulose filter attached to a syringe. The resulting solution is yellow. |
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