| Name | mAMSA
amsacrine (N-[4-(9-acridinylamino)-3-methoxyphenyl]methanesulphonanilide) |
| CAS# | 51264-14-3 |
| NCS# | 249992 |
| MW | 393.46 |
| Category | Acridine |
| Binding Mode | Intercalation of acridine ring, possibly threading [Bailly, 1992 #750]. Methanesulfon-m-ansidine ring in minor groove. |
| Site Specificity | Initially considered to have slight A/T preference based on spectrophotometry
[Wilson, 1981] and theoretical predication [Wilson, 1981], but G/C preference
demonstrated by DNase footprinting [Bailly, 1992].
|
| Effect on DNA | DNA unwinding angle of 20o [Wilson, 1981]. |
| Preparation and Use | Dissolve in 5 mM DMSO |
| DNA drugs |
| Heme-Onc |
| Netscut Home |